Prof.   Chruma’s research interest focus on developing new methods for the synthesis   of nitrogen-containing organic compounds and other biologically-active   natural products involving such “green” methods as transition-metal catalyzed   decarboxylative alkylations and intramolecular pericyclic reactions. The   intent is to discover new molecular probes and tools to elucidate the   biomolecular mechanisms involved in cellular differentiation and aniokis. Additional   interests involve the design and synthesis of novel foldamer scaffolds and   fluorescent linchpin reagents for bioconjugate synthesis.